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排序方式: 共有1547条查询结果,搜索用时 31 毫秒
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Michael L. Alosco PhD Jesse Mez MD MS Yorghos Tripodis PhD Patrick T. Kiernan BA Bobak Abdolmohammadi BA Lauren Murphy BA Neil W. Kowall MD Thor D. Stein MD PhD Bertrand Russell Huber MD PhD Lee E. Goldstein MD PhD Robert C. Cantu MD Douglas I. Katz MD Christine E. Chaisson MPH Brett Martin MS Todd M. Solomon PhD Michael D. McClean ScD Daniel H. Daneshvar MD PhD Christopher J. Nowinski PhD Robert A. Stern PhD Ann C. McKee MD 《Annals of neurology》2018,83(5):886-901
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Hilde M. Norum Annika E. Michelsen Tove Lekva Satish Arora Kari Otterdal Maria Belland Olsen Xiang Yi Kong Einar Gude Arne K. Andreassen Dag Solbu Kristjan Karason Gran Dellgren Lars Gullestad Pl Aukrust Thor Ueland 《American journal of transplantation》2019,19(4):1050-1060
Cardiac allograft vasculopathy (CAV) causes heart failure after heart transplantation (HTx), but its pathogenesis is incompletely understood. Notch signaling, possibly modulated by everolimus (EVR), is essential for processes involved in CAV. We hypothesized that circulating Notch ligands would be dysregulated after HTx. We studied circulating delta‐like Notch ligand 1 (DLL1) and periostin (POSTN) and CAV in de novo HTx recipients (n = 70) randomized to standard or EVR‐based, calcineurin inhibitor‐free immunosuppression and in maintenance HTx recipients (n = 41). Compared to healthy controls, plasma DLL1 and POSTN were elevated in de novo (P < .01; P < .001) and maintenance HTx recipients (P < .001; P < .01). Use of EVR was associated with a treatment effect for DLL1. For de novo HTx recipients, a change in DLL1 correlated with a change in CAV at 1 (P = .021) and 3 years (P = .005). In vitro, activation of T cells increased DLL1 secretion, attenuated by EVR. In vitro data suggest that also endothelial cells and vascular smooth muscle cells (VSMCs) could contribute to circulating DLL1. Immunostaining of myocardial specimens showed colocalization of DLL1 with T cells, endothelial cells, and VSMCs. Our findings suggest a role of DLL1 in CAV progression, and that the beneficial effect of EVR on CAV could reflect a suppressive effect on DLL1. Trial registration numbers— SCHEDULE trial: ClinicalTrials.gov NCT01266148; NOCTET trial: ClinicalTrials.gov NCT00377962. 相似文献
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Klara Miriam Elfström Karin Sundström Sonia Andersson Zurab Bzhalava Agneta Carlsten Thor Zohra Gzoul Daniel Öhman Helena Lamin Carina Eklund Joakim Dillner Sven Törnberg 《International journal of cancer. Journal international du cancer》2019,145(11):3033-3039
High screening participation in the population is essential for optimal prevention of cervical cancer. Offering a high-risk human papillomavirus (HPV) self-test has previously been shown to increase participation. In this randomized health services study, we evaluated four strategies with regard to participation. Women who had not attended organized cervical screening in 10 years were eligible for inclusion. This group comprised 16,437 out of 413,487 resident women ages 33–60 (<4% of the screening target group). Among these 16,437 long-term nonattenders, 8,000 women were randomized to either (i) a HPV self-sampling kit sent directly; (ii) an invitation to order a HPV self-sampling kit using a new open source eHealth web application; (iii) an invitation to call a coordinating midwife with questions and concerns; or (iv) the standard annual renewed invitation letter with prebooked appointment time (routine practice). Overall participation, by arm, was (i) 18.7%; (ii) 10.7%; (iii) 1.9%; and (iv) 1.7%. The relative risk of participation in Arm 1 was 11.0 (95% CI 7.8–15.5), 6.3 (95% CI 4.4–8.9) in Arm 2 and 1.1 (95% CI 0.7–1.7) in Arm 3, compared to Arm 4. High-risk HPV prevalence among women who returned kits in study Arms 1 and 2 was 12.2%. In total, 63 women were directly referred to colposcopy from Arms 1 and 2; of which, 43 (68.3%) attended and 17 had a high-grade cervical lesion (CIN2+) in histology (39.5%). Targeting long-term nonattending women with sending or offering the opportunity to order self-sampling kits further increased the participation in an organized screening program. 相似文献
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Randomized assessment of imatinib in patients with acute ischaemic stroke treated with intravenous thrombolysis 下载免费PDF全文
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Camden Hebson MD Wendy Book MD Robert W. Elder MD Ryan Ford MD Maan Jokhadar MD Kirk Kanter MD Brian Kogon MD Adrienne H. Kovacs PhD Rebecca D. Levit MD Michael Lloyd MD Kevin Maher MD Preeti Reshamwala MD Fred Rodriguez III MD Rene Romero MD Thor Tejada MD Anne Marie Valente MD Gruschen Veldtman MD Michael McConnell MD 《Congenital heart disease》2017,12(1):6-16
“Frontiers in Fontan Failure” was the title of a 2015 conference sponsored by Children's Healthcare of Atlanta and Emory University School of Medicine. In what is hoped to be the first of many such gatherings, speakers and attendees gathered to discuss the problem of long‐term clinical deterioration in these patients. Specific focuses included properly defining the problem and then discussing different treatment strategies, both medical and surgical. The health of the liver after Fontan palliation was a particular point of emphasis, as were quality of life and future directions. 相似文献
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Beverly Barton Rogers Scott D. Berns Edward C. Maynard Thor W. R. Hansen 《Fetal and pediatric pathology》1990,10(5):819-823
A very low birthweight infant developed pericardial tamponade secondary to leakage of fat emulsion through a catheter lodged in the right atrial appendage. At autopsy examination a thrombus was lodged in the appendage, which presumably resulted in immobilization of the catheter and leakage of the fluid through an attenuated and necrotic myocardial wall. 相似文献